Peter Parker is an outcast high schooler who was abandoned by his parents as a boy, leaving him to be raised by his Uncle Ben and Aunt May. As he discovers a mysterious briefcase that belonged to his father, he begins a quest to understand his parents' disappearance - leading him directly to OsCorp and the lab of Dr. Curt Connors. As Spider-Man is set on a collision course with Connors' alter-ego, The Lizard, Peter will make life-altering choices to use his powers and shape his destiny to become a hero.